Sodium Thiosulfate → HCID 57940688, compound

Participants

Reaction Steps

At 0° C., 3-chloroperbenzoic acid (0.260 g) was added to a solution of 4-[1-(6-methoxy-3-pyridyl)-5-(4-methylthio-2-pyridyl)pyrazole-3-carbonyl]piperazine-1-carboxylic acid tert-butyl ester (0.366 g) obtained in Example 47 in methylene chloride (7.3 mL), and the mixture was stirred for 20 minutes. Subsequently, the mixture was stirred at room temperature for a further 2 hours. At 0° C., 3-chloroperbenzoic acid (0.124 g) was added thereto, and the resultant mixture was stirred for 2 hours. Saturated aqueous sodium thiosulfate (10 mL) and saturated aqueous sodium hydrogencarbonate (10 mL) were added to the reaction mixture, followed by stirring. The reaction mixture was partitioned between water and chloroform. The organic layer was dried over sodium sulfate anhydrate. After filtration, the solvent was removed under reduced pressure. The residue was purified through silica gel column chromatography (chloroform-methanol), to thereby give the title compound as an amorphous product (0.387 g, 99%).

Provenance & Evidence