Pyrrolidine → HCID 57940683, compound

Participants

Reaction Steps

A solution of 4-[1-(6-methoxy-3-pyridyl)-5-(4-methylsulfonyl-2-pyridyl)pyrazole-3-carbonyl]piperazine-1-carboxylic acid tert-butyl ester (0.186 g) obtained in Example 48 in pyrrolidine (3.7 mL) was stirred at 100° C. for 17 hours, and then the mixture was cooled in air. The reaction mixture was partitioned between water and ethyl acetate. The organic layer was dried over sodium sulfate anhydrate. After filtration, the solvent was removed under reduced pressure. The residue was purified through silica gel column chromatography (chloroform-methanol), to thereby give the title compound as a solid (0.176 g, 96%).

Provenance & Evidence