Lawesson's reagent → HCID 57940706, compound

Participants

Reaction Steps

To a solution of 1-[1-(6-methoxy-3-pyridyl)-5-phenylpyrazole-3-carbonyl]-4-methylpiperazine (173 mg) obtained in Example 62 in toluene (10 mL), 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide (Lawson reagent, 222 mg) was added. The mixture was refluxed for 14 hours under heat. The reaction mixture was partitioned between water and ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogencarbonate, water, and saturated brine, followed by drying over sodium sulfate anhydrate. After filtration, the solvent was removed under reduced pressure. The residue was purified through silica gel thin-layer chromatography (chloroform-methanol), to thereby give the title compound as an amorphous product (61 mg, 33%).

Provenance & Evidence