Potassium Cyanide → HCID 57940678, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-[5-(4-methanesulfonyl-2-pyridyl)-1-(6-methoxy-3-pyridyl)pyrazole-3-carbonyl]piperidine (0.60 g) obtained in Example 97 in N,N-dimethylformamide (12 mL), potassium cyanide (97.3 mg) was added at room temperature. The mixture was stirred at 120° C. for 37 hours, and then potassium cyanide (97.3 mg) was further added thereto. The mixture was further stirred at 120° C. for 4 hours, and then cooled in air. The reaction mixture was partitioned between saturated brine and ethyl acetate. The organic layer was dried over sodium sulfate anhydrate. After filtration, the solvent was removed under reduced pressure, and the residue was purified through silica gel column chromatography (chloroform-ethyl acetate), to thereby give the title compound as a solid (0.441 g, 84%).

Provenance & Evidence