Methanol → HCID 57940711, compound

Participants

Reaction Steps

To a solution of 1-[5-(4-cyano-2-pyridyl)-1-(6-methoxy-3-pyridyl)pyrazole-3-carbonyl]piperidine (0.418 g) obtained in Example 98 in a mixture of methanol (8.4 mL) and tetrahydrofuran (8.4 mL), 1N aqueous sodium hydroxide (5.38 mL) was added at room temperature. The resultant mixture was stirred at 80° C. for 7 hours, and then cooled in air. The reaction mixture was partitioned between water and chloroform. The aqueous layer was neutralized to pH 6 with 1N aqueous hydrochloric acid. Chloroform was added for partitioning to the aqueous layer. The aqueous layer was further extracted with chloroform. The organic layers were combined and dried over sodium sulfate anhydrate. After filtration, the solvent was removed under reduced pressure, to thereby give the title compound as a solid (0.239 g, 52%).

Provenance & Evidence