Acetyl chloride → HCID 23090451, compound

Participants

Reaction Steps

At 0° C., triethylamine (0.205 mL) and acetyl chloride (0.0447 mL) were added to a solution of 4-[1-(6-methoxy-3-pyridyl)-5-(2-pyridyl)pyrazole-3-carbonyl]piperazine hydrochloride (0.185 g) obtained in Example 81 in methylene chloride (5.0 mL). The mixture was stirred at room temperature for 1 hour. The reaction mixture was partitioned between water and chloroform. The aqueous layer was further extracted with chloroform, and the organic layers were combined, followed by washing with saturated brine and drying over sodium sulfate anhydrate. After filtration, the solvent was removed under reduced pressure. The residue was purified through silica gel column chromatography (chloroform-methanol), to thereby give the title compound as an amorphous product (0.147 g, 87%).

Provenance & Evidence