4-Chloroquinoline → HCID 178453960, compound

HRID 1437323Notes

Reaction equation

Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[C:12]([O:16][C:17](=[O:28])[NH:18][C@H:19]1[CH2:24][CH2:23][C@H:22]([C:25](=[O:27])[NH2:26])[CH2:21][CH2:20]1)([CH3:15])([CH3:14])[CH3:13]>>[C:12]([O:16][C:17](=[O:28])[NH:18][C@H:19]1[CH2:24][CH2:23][C@H:22]([C:25](=[O:27])[NH:26][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=[CH:4][CH:3]=2)[CH2:21][CH2:20]1)([CH3:15])([CH3:13])[CH3:14]

Participants

Reactant 2

HCID 691404-Chloroquinoline

HCID 178453950HCID 178453950, compound

Product 1

HCID 178453960HCID 178453960, compoundYield 60%

Procedure

This was prepared from 4-chloroquinoline (0.49 g) and amide (a) (0.73 g) according to the procedure of Example (1l) affording a white solid (0.66 g, 60%).

Sources & evidence

ORD record: ord-ad8f0687b30d42689c1c7289613939ff
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07622481B2

Reaction notes

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