Acetic acid methanol → (1R,3R,4R)-4-amino-3-hydroxy-cyclohexanecarboxylic acid amide, acetate salt

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Reaction Steps

To (1R,3R,4R)-4-azido-3-hydroxy-cyclohexanecarboxylic acid amide (c) (765 mg, 4.15 mmol) in MeOH/AcOH (9:1, 30 mL) was added Pd/C (10%, 300 mg), and the mixture stirred under hydrogen at atmospheric pressure for 22 hours. The mixture was filtered through Celite®, the residue washed with MeOH, and the combined organic extracts concentrated in vacuo to give a white solid (905 mg, 100%).

Provenance & Evidence