HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyl chloroformate → 7-(hydroxymethyl)-1H-pyrido[2,3-b][1,4]thiazin-2(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyl chloroformate | HCID 62365 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 2,3-Dihydro-2-oxo-1H-pyrido[2,3-b][1,4]thiazine-7-carboxylic acid | HCID 21873692 | — |
| Product | 7-(hydroxymethyl)-1H-pyrido[2,3-b][1,4]thiazin-2(3H)-one | HCID 21873728 | 56.2% |
Reaction Steps
The carboxylic acid (c) (2.48 g) was reacted with isobutylchloroformate and sodium borohydride by the method of Example (1i) to afford a solid (1.3 g), after recrystallisation from chloroform-methanol (9:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622481B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-bba5c0adef1040c3b7cee492f38fd170 |
| Source note | uspto-grants-2009_11 |