Nitric Acid → HCID 68700280, compound

Participants

Reaction Conditions

Reaction Steps

The pyridine N-oxide (b) (18.5 g) was dissolved in a cold mixture of fuming nitric acid (90 ml) and concentrated sulfuric acid (90 ml) and heated to 40° C. for 1 hour, then 65° C. overnight. The mixture was cooled, poured onto ice and EtOAc (250 ml) added. When the ice had melted, the mixture was shaken and solid filtered off The EtOAc was dried and evaporated, the residue triturated with ether and filtered affording a solid (8.4 g).

Provenance & Evidence