HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1437350Generated: November 3, 2026
Tetrahydrofuran → 2-Oxo-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazine-7-carbaldehyde
https://huagongshe.com/reaction/1437350
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | HCID 21873679 | HCID 21873679 | — |
| Catalyst | HCID 178418406 | HCID 178418406 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 2-Oxo-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazine-7-carbaldehyde | HCID 21873602 | — |
Reaction Steps
A mixture of the hydroxymethyloxazinone (h) (584 mg), manganese dioxide (2.3 g), THF (50 ml) and 1,2-dichloroethane (50 ml) was heated at 60° C. under argon for 20 hours. Filtration through kieselguhr and evaporation of solvent gave a solid which was triturated under EtOAc/hexane 1:3, filtered off and dried (383 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07622481B2 |
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| Source dataset | uspto-grants-2009_11 |
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| ORD ID | ord-da07e9a5c0f947f68be1017a0335149a |
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| Source note | uspto-grants-2009_11 |
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