HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-Bromo-5-methoxyquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 5-Methoxyquinolin-4-ol | HCID 23595324 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Bromo-5-methoxyquinoline | HCID 53407899 | 85% |
Reaction Steps
A solution of quinolone (c) (3.2 g, 18 mmol) in DMF (22 ml) was treated with phosphorous tribromide (2.2 ml). After 2 hours the mixture was added to water and neutralised with saturated aqueous sodium bicarbonate solution. Filtration and drying afforded a yellow solid (3.6 g, 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622481B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-89be9971a06b456681e9222a6f13db82 |
| Source note | uspto-grants-2009_11 |