Ammonia → HCID 57941060, compound

Participants

Reaction Steps

Ketone (b) (1.02 g, 5.4 mmol) in dichloroethane (24 mL) and acetic acid (1 mL) was treated with (R)-α-methyl benzylamine (0.88 mL) and sodium triacetoxyborohydride (2.2 g). After 4.5 hours, the reaction mixture was loaded onto a silica gel column packed in 0.5% (2M ammonia in methanol) in dichloromethane and eluted with 0.5-10% (2M ammonia in methanol) in dichloromethane to give an oil (1.2 g).

Provenance & Evidence