HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) → 4-Hydroxyquinoline-6-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) | HCID 24670 | — |
| Reactant | 4-(((2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzonitrile | HCID 11694705 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 4-Hydroxyquinoline-6-carbonitrile | HCID 11658351 | 94.3% |
Reaction Steps
Benzonitrile (a) (27.5 g) was added portionwise over 5 minutes to refluxing Dowtherm A (200 ml). After refluxing an additional 5 minutes, the mixture was allowed to cool to room temperature and diluted with ether (200 ml) with stirring. The product was filtered off, washed thoroughly with ether and air dried to provide a gold solid (16.2 g, 94%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622481B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-3be0c4741a29485f881d876f25db75a7 |
| Source note | uspto-grants-2009_11 |