Boron tribromide → HCID 57941176, compound

Participants

Reaction Conditions

Reaction Steps

To a flask equipped with stir bar was added benzyl 4-(2,5-difluorophenyl)-6-(3-methoxyphenyl)-3,6-dihydropyridine-1(2H)-carboxylate (1-4, 0.51 g, 1.17 mmol) and dichloromethane (20 mL). The resulting solution was cooled to 0° C. and treated with BBr3 (0.15 mL, 1.17 mmol). The reaction was stirred at 0° C. for 4 h, then warmed to 23° C. Upon completion, the reaction was diluted with dichloromethane (100 mL) and washed with water (3×100 mL). The organics were dried over sodium sulfate, filtered, and concentrated under reduced pressure. The crude product was carried into the subsequent acylation.

Provenance & Evidence