Water → HCID 57941023, compound

Participants

Reaction Steps

2-[[2-(3-methoxyphenyl)-6-phenyl-1H-imidazo[4,5-b]pyridin-1-yl]methyl]phenyl acetate (Compound of Example 153) (177 mg) was dissolved in tetrahydrofuran-methanol (1:1, v/v, 20 ml). To the solution was added 2 N lithium hydroxide (6.8 ml). The mixture was stirred at room temperature for 1.5 hour. The reaction mixture was poured into water and extracted with ethyl acetate-tetrahydrofuran (3:1, v/v). The organic layer was washed with water and dried over MgSO4. The solvent was distilled off under reduced pressure, and the resulting crystals were collected by filtration to obtain 2-[[2-(3-methoxyphenyl)-6-phenyl-1H-imidazo[4,5-b]pyridin-1-yl]methyl]phenol (133 mg, 83%). The crystals were recrystallized from tetrahydrofuran-ethyl acetate.

Provenance & Evidence