Hydrochloric Acid → HCID 57940911, compound

Participants

Reaction Steps

[2-[[2-(3-methoxyphenyl)-6-phenyl-1H-imidazo[4,5-b]pyridin-1-yl]methyl]phenoxy]ethyl acetate (Compound of Example 158) (28 mg) was dissolved in tetrahydrofuran-ethanol (1:1, v/v, 3.6 ml), and to the solution was added 2 N lithium hydroxide (1.2 ml). The mixture was stirred at room temperature for 2 hours. The reaction mixture was poured into water, and to the mixture was added 2 N hydrochloric acid to adjust the pH to 3. The mixture was extracted with ethyl acetate-tetrahydrofuran (3:1, v/v). The organic layer was washed with water and dried over MgSO4. The solvent was distilled off under reduced pressure and the resulting crystals were collected by filtration to obtain [2-[[2-(3-methoxyphenyl)-6-phenyl-1H-imidazo[4,5-b]pyridin-1-yl]methyl]phenoxy]acetic acid (15 mg, 55%).

Provenance & Evidence