Water → HCID 23025907, compound

Participants

Reaction Steps

To a solution of tert-butyl [3-(6-bromobenzoxazol-2-yl)phenoxy]acetate (Compound of Example 279) (2.22 g) in tetrahydrofuran (10 ml) was added 4 N hydrochloric acid-ethyl acetate (50 ml), and the mixture was stirred at room temperature for 2 hours. The reaction mixture was poured into water and extracted with ethyl acetate-tetrahydrofuran (3:1, v/v). The organic layer was washed with water and dried over MgSO4. The solvent was distilled off under reduced pressure, and the resulting crystals were collected by filtration to obtain [3-(6-bromobenzoxazol-2-yl)phenoxy]acetic acid (1.27 g, 66%). The crystals were recrystallized from tetrahydrofuran-ethyl acetate.

Provenance & Evidence