3-Methoxybenzoic Acid → HCID 23025927, compound

Participants

Reaction Conditions

Reaction Steps

6-Phenoxy-2,3-pyridine diamine (Compound of Reference Example 115) (0.2 g) and 3-methoxybenzoic acid (0.08 g) were dissolved in phosphorus oxychloride (5 ml) and the solution was stirred at 140° C. for 4 hours. The reaction mixture was poured onto ice, neutralized with 8 N sodium hydroxide solution and extracted with ethyl acetate-tetrahydrofuran (3:1, v/v). The organic layer was washed with water and dried over MgSO4. The solvent was distilled off under reduced pressure, and the resulting crystals were collected by filtration to obtain 5-phenoxy-2-(3-methoxyphenyl)-1H-imidazo[4,5-b]pyridine (0.04 g, 23%).

Provenance & Evidence