HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)aniline → 6-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-carbazol-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)aniline | HCID 9964 | — |
| Reactant | Cyclohexanone, 2-(hydroxymethylene)- | HCID 101871 | — |
| Product | 6-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-carbazol-1-one | HCID 752602 | — |
Reaction Steps
6-(Trifluoromethyl)-2,3,4,9-tetrahydro-1H-carbazol-1-one was prepared from 4-(trifluoromethyl)aniline (5.5 g, 34 mmol) and 2-(hydroxymethylene)cyclohexanone (3.9 g, 31 mmol) in a similar manner as described above to give 2.25 g (29%). of a dark brown solid. 1H-NMR (DMSO-d6): δ 12.05 (s, 1H), 8.11 (s, 1H), 7.56 (s, 2H), 3.00 (t, 2H), 2.58 (t, 2H), 2.19-2.13 (m, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622494B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-14c01197cb624dc4ab1c7d914e31aa96 |
| Source note | uspto-grants-2009_11 |