Sulfuric Acid → HCID 24991591, compound

HRID 1437620Notes

Reaction equation

HRID 1437620 reaction equation
[C:1]1([CH:7]([CH2:10][OH:11])[C:8]#[N:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13].S(=O)(=O)(O)O>C(#N)C>[C:12]([O:11][CH2:10][CH:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[C:8]#[N:9])(=[O:14])[CH3:13]

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 7918Acetic AnhydrideHCID 110080653-HYDROXY-2-PHENYLPROPIONITRILE

Product 1

HCID 24991591HCID 24991591, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A sample of this 2-phenyl-3-hydroxypropanenitrile (127 mg, 0.863 mmol) and acetic anhydride (106 μL, 1.1 mmol) in acetonitrile (250 μL) was treated with sulfuric acid (˜0.5 μL). After 25 min at ambient temperature, work-up as described above in Example 5 gave 160 mg (98%) product as a colorless oil.

Sources & evidence

ORD record
ord-16347fd828de4de9b8e9b929b4bef079
Source dataset
uspto-grants-2009_11
Patent number
US07622504B2

Reaction notes

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