Ethyl bromoacetate → HCID 86606813, compound

HRID 1437635Notes

Reaction equation

HRID 1437635 reaction equation
Cl.[F:2][C:3]([F:29])([F:28])[C:4]1[CH:5]=[C:6]([CH:21]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:23]=1)[CH2:7][O:8][C@H:9]1[CH2:14][CH2:13][NH:12][CH2:11][C@H:10]1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.Br[CH2:31][C:32]([O:34][CH2:35][CH3:36])=[O:33]>>[CH2:35]([O:34][C:32](=[O:33])[CH2:31][N:12]1[CH2:13][CH2:14][C@H:9]([O:8][CH2:7][C:6]2[CH:21]=[C:22]([C:24]([F:27])([F:25])[F:26])[CH:23]=[C:4]([C:3]([F:2])([F:28])[F:29])[CH:5]=2)[C@H:10]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:11]1)[CH3:36]

Participants

3

Reactant 2

HCID 7748Ethyl bromoacetateHCID 86606807cis-4-[[3,5-Bis(trifluoromethyl)benzyl]oxy]-3-phenylpiperidine hydrochloride

Product 1

HCID 86606813HCID 86606813, compoundYield 42.8%

Procedure

The compound (0.21 g) obtained in Example 1 and ethyl bromoacetate (0.17 g) were reacted and treated in the same manner as in the method described in Example 7 to obtain the title compound as colorless oil (0.10 g, 42%).

Workup

  1. additiontreated in the same manner as in the method

Sources & evidence

ORD record
ord-45a84d2c50e74d09b9fbfc93d8e706cd
Source dataset
uspto-grants-2009_11
Patent number
US07622487B2

Reaction notes

Loading…