Phenyl isocyanate → HCID 86606817, compound

HRID 1437639Notes

Reaction equation

HRID 1437639 reaction equation
Cl.[F:2][C:3]([F:29])([F:28])[C:4]1[CH:5]=[C:6]([CH:21]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:23]=1)[CH2:7][O:8][C@H:9]1[CH2:14][CH2:13][NH:12][CH2:11][C@H:10]1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[C:30]1([N:36]=[C:37]=[O:38])[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[F:29][C:3]([F:2])([F:28])[C:4]1[CH:5]=[C:6]([CH:21]=[C:22]([C:24]([F:27])([F:25])[F:26])[CH:23]=1)[CH2:7][O:8][C@H:9]1[CH2:14][CH2:13][N:12]([C:37]([NH:36][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[O:38])[CH2:11][C@H:10]1[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 7672Phenyl isocyanateHCID 86606807cis-4-[[3,5-Bis(trifluoromethyl)benzyl]oxy]-3-phenylpiperidine hydrochloride

Product 1

HCID 86606817HCID 86606817, compoundYield 67%

Procedure

The compound (0.15 g) obtained in Example 1 and phenyl isocyanate (0.074 ml) were reacted and treated in the same maimer as in the method described in Example 6 to obtain the title compound as colorless oil (0.12 g, 67%).

Workup

  1. additiontreated in the same maimer as in the method

Sources & evidence

ORD record
ord-fd786c66c4db48d08c9c212be441f5b2
Source dataset
uspto-grants-2009_11
Patent number
US07622487B2

Reaction notes

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