Ethyl isocyanate → HCID 86606818, compound

HRID 1437640Notes

Reaction equation

HRID 1437640 reaction equation
Cl.[F:2][C:3]([F:29])([F:28])[C:4]1[CH:5]=[C:6]([CH:21]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:23]=1)[CH2:7][O:8][C@H:9]1[CH2:14][CH2:13][NH:12][CH2:11][C@H:10]1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[CH2:30]([N:32]=[C:33]=[O:34])[CH3:31]>>[F:29][C:3]([F:2])([F:28])[C:4]1[CH:5]=[C:6]([CH:21]=[C:22]([C:24]([F:27])([F:25])[F:26])[CH:23]=1)[CH2:7][O:8][C@H:9]1[CH2:14][CH2:13][N:12]([C:33]([NH:32][CH2:30][CH3:31])=[O:34])[CH2:11][C@H:10]1[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 8022Ethyl isocyanateHCID 86606807cis-4-[[3,5-Bis(trifluoromethyl)benzyl]oxy]-3-phenylpiperidine hydrochloride

Product 1

HCID 86606818HCID 86606818, compoundYield 74%

Procedure

The compound (0.20 g) obtained in Example 1 and ethyl isocyanate (0.047 g) were reacted and treated in the same manner as in the method described in Example 6 to obtain the title compound as colorless oil (0.12 g, 74%).

Workup

  1. additiontreated in the same manner as in the method

Sources & evidence

ORD record
ord-4623356adb134d198d62c194282976d5
Source dataset
uspto-grants-2009_11
Patent number
US07622487B2

Reaction notes

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