2-Pyridineacetic acid, hydrochloride (1:1) → HCID 86761003, compound

HRID 1437650Notes

Reaction equation

HRID 1437650 reaction equation
Cl.[CH:2]([C@H:15]1[C@@H:20]([O:21][CH2:22][C:23]2[CH:28]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:26]=[C:25]([C:33]([F:36])([F:35])[F:34])[CH:24]=2)[CH2:19][CH2:18][NH:17][CH2:16]1)([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl.[N:38]1[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=1[CH2:44][C:45](O)=[O:46]>>[CH:2]([C@H:15]1[C@@H:20]([O:21][CH2:22][C:23]2[CH:28]=[C:27]([C:29]([F:30])([F:31])[F:32])[CH:26]=[C:25]([C:33]([F:36])([F:34])[F:35])[CH:24]=2)[CH2:19][CH2:18][N:17]([C:45](=[O:46])[CH2:44][C:39]2[CH:40]=[CH:41][CH:42]=[CH:43][N:38]=2)[CH2:16]1)([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 853172-Pyridineacetic acid, hydrochloride (1:1)HCID 86760996HCID 86760996, compound

Product 1

HCID 86761003HCID 86761003, compound

Procedure

The compound (31.8 mg) obtained in Example 25 and 2-pyridineacetic acid hydrochloride (20.8 mg) were reacted and treated in the same manner as in the method described in Example.32 to obtain the title compound.

Workup

  1. additiontreated in the same manner as in the method

Sources & evidence

ORD record
ord-4dcb546ba74a4444b297535f22c5119a
Source dataset
uspto-grants-2009_11
Patent number
US07622487B2

Reaction notes

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