HCID 86760996, compound → HCID 178520347, compound

HRID 1437651Notes

Reaction equation

HRID 1437651 reaction equation
Cl.[CH:2]([C@H:15]1[C@@H:20]([O:21][CH2:22][C:23]2[CH:28]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:26]=[C:25]([C:33]([F:36])([F:35])[F:34])[CH:24]=2)[CH2:19][CH2:18][NH:17][CH2:16]1)([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl.[NH:38]1[CH:42]=[C:41]([CH2:43][C:44](O)=[O:45])[N:40]=[CH:39]1>>[CH:2]([C@H:15]1[C@@H:20]([O:21][CH2:22][C:23]2[CH:28]=[C:27]([C:29]([F:30])([F:31])[F:32])[CH:26]=[C:25]([C:33]([F:36])([F:34])[F:35])[CH:24]=2)[CH2:19][CH2:18][N:17]([C:44](=[O:45])[CH2:43][C:41]2[N:40]=[CH:39][NH:38][CH:42]=2)[CH2:16]1)([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 86760996HCID 86760996, compoundHCID 178479752HCID 178479752, compound

Product 1

HCID 178520347HCID 178520347, compound

Procedure

The compound (31.8 mg) obtained in Example 25 and 4-imidazoleacetic acid hydrochloride (19.5 mg) were reacted and treated in the same manner as in the method described in Example 32 to obtain the title compound.

Workup

  1. additiontreated in the same manner as in the method

Sources & evidence

ORD record
ord-dc7d7e66959f4bce88d2a24c84999f5b
Source dataset
uspto-grants-2009_11
Patent number
US07622487B2

Reaction notes

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