3,5-Bis(trifluoromethyl)benzoic acid → HCID 86761010, compound

HRID 1437670Notes

Reaction equation

HRID 1437670 reaction equation
Cl.[CH:2]([C@H:15]1[C@@H:20]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([O:29][C:30]([F:33])([F:32])[F:31])[CH:24]=2)[CH2:19][CH2:18][NH:17][CH2:16]1)([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[F:34][C:35]([F:50])([F:49])[C:36]1[CH:37]=[C:38]([CH:42]=[C:43]([C:45]([F:48])([F:47])[F:46])[CH:44]=1)[C:39](O)=[O:40]>>[CH:2]([C@H:15]1[C@@H:20]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([O:29][C:30]([F:33])([F:31])[F:32])[CH:24]=2)[CH2:19][CH2:18][N:17]([C:39](=[O:40])[C:38]2[CH:42]=[C:43]([C:45]([F:46])([F:47])[F:48])[CH:44]=[C:36]([C:35]([F:34])([F:49])[F:50])[CH:37]=2)[CH2:16]1)([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 128893,5-Bis(trifluoromethyl)benzoic acidHCID 69060300HCID 69060300, compound

Product 1

HCID 86761010HCID 86761010, compound

Procedure

The compound (27.7 mg) obtained in Example 27 and 3,5-bis(trifluoromethyl)benzoic acid (31.0 mg) were reacted and treated in the same manner as in the method described in Example 33 to obtain the title compound.

Workup

  1. additiontreated in the same manner as in the method

Sources & evidence

ORD record
ord-77235ec9deb94ce6bd416fb8e6f5dabd
Source dataset
uspto-grants-2009_11
Patent number
US07622487B2

Reaction notes

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