HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propionic Acid → HCID 86606830, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propionic Acid | HCID 1032 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | cis-4-[[3,5-Bis(trifluoromethyl)benzyl]oxy]-3-phenylpiperidine hydrochloride | HCID 86606807 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86606830 | HCID 86606830 | — |
Reaction Steps
To a solution of the compound (132 mg) obtained in Example 1, propionic acid (32 mg) and Et3N (0.083 ml) in DMF (5 ml), WSC.HCl (0.15 g) and HoBt.H2O (0.092 g) were added, and the reaction mixture was stirred at room temperature for 24 hours. The reaction mixture was poured into water, and then the product was extracted with ethyl acetate. The organic layer was washed with an aqueous saturated sodium hydrogen carbonate solution and saturated brine, dried, and then the solvent was evaporated under reduced pressure. The obtained residue was purified by preparative HPLC to obtain the title compound as colorless amorphous.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622487B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-3c7d2782492c406bb1bf2e1e609c4e15 |
| Source note | uspto-grants-2009_11 |