HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 86761012, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | N-(tert-butoxycarbonyl)glycine | HCID 78288 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | cis-4-[[3,5-Bis(trifluoromethyl)benzyl]oxy]-3-phenylpiperidine hydrochloride | HCID 86606807 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 86761012 | HCID 86761012 | — |
Reaction Steps
To a solution of the compound (35 mg) obtained in Example 1, Boc-glycine (15 mg) and Et3N (22 μl) in DMF (2.0 ml), WSC.HCl (17 mg) and HoBt.H2O (13 mg) were added, and the reaction mixture was stirred at room temperature for 24 hours. The reaction mixture was poured into water, and then the product was extracted with ethyl acetate. The organic layer was washed with an aqueous saturated sodium hydrogen carbonate solution and saturated brine, and dried, and the solvent was evaporated under reduced pressure, and then the residue was purified by preparative HPLC. To the obtained product, trifluoroacetic acid (1 ml) was added and the reaction mixture was stirred for 1 hour, and then the solvent was evaporated to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622487B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-95fbe56526c748f0a45524356586ebfd |
| Source note | uspto-grants-2009_11 |