HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-3-chloropropane → 5-(3-Chloro-propoxy)-2-(4,4-difluoro-piperidine-1-carbonyl)-pyrrolo[2,3-b]pyridine-1-carboxylic Acid tert-butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-3-chloropropane | HCID 8006 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-(4,4-Difluoro-piperidine-1-carbonyl)-5-hydroxy-pyrrolo[2,3-b]pyridine-1-carboxylic Acid tert-butyl Ester | HCID 68423977 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 5-(3-Chloro-propoxy)-2-(4,4-difluoro-piperidine-1-carbonyl)-pyrrolo[2,3-b]pyridine-1-carboxylic Acid tert-butyl Ester | HCID 68425223 | 63% |
Reaction Steps
The title compound was synthesized in analogy to example 1, intermediate a), from 2-(4,4-difluoro-piperidine-1-carbonyl)-5-hydroxy-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester, potassium carbonate and 1-bromo-3-chloropropane in 2-butanone to give the desired product as a colorless foam (63%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622466B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-6ffcffd3d9ce4eedacb7082a7fd1308f |
| Source note | uspto-grants-2009_11 |