HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → HCID 16727131, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 68424295 | HCID 68424295 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 16727131 | HCID 16727131 | 33% |
Reaction Steps
The title compound was synthesized in analogy to example 9, intermediate a), from lithium 1-tert-butoxycarbonyl-5-(1-isopropyl-piperidin-4-yloxy)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate, O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate, pyrrolidine and N,N-diisopropylethylamine in DMF to give the desired product as a light yellow solid (33%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622466B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-17b3b393c2e04b159be8303019041b52 |
| Source note | uspto-grants-2009_11 |