HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → (4,4-Difluoro-piperidin-1-yl)-{1-methanesulfonyl-5-[3-((S)-2-methyl-pyrrolidin-1-yl)-propoxy]-1H-pyrrolo[2,3-b]pyridin-2-yl}-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | (4,4-Difluoro-piperidin-1-yl)-[5-[3-((S)-2-methyl-pyrrolidin-1-yl)-propoxy]-1H-pyrrolo[2,3-b]pyridin-2-yl]-methanone | HCID 16727354 | — |
| Product | (4,4-Difluoro-piperidin-1-yl)-{1-methanesulfonyl-5-[3-((S)-2-methyl-pyrrolidin-1-yl)-propoxy]-1H-pyrrolo[2,3-b]pyridin-2-yl}-methanone | HCID 16727133 | 52% |
Reaction Steps
The title compound was synthesized in analogy to example 18 from (4,4-difluoro-piperidin-1-yl)-{5-[3-((S)-2-methyl-pyrrolidin-1-yl)-propoxy]-1H-pyrrolo[2,3-b]pyridin-2-yl}-methanone (example 11), sodium hydride and methanesulfonyl chloride, to give the desired product as a light yellow oil (52%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622466B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-cadb22630ab740559d86eeb130dc3995 |
| Source note | uspto-grants-2009_11 |