HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 16727136, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Bromomethylcyclopropane | HCID 81503 | — |
| Reactant | (4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-pyrrolo[2,3-b]pyridin-2-yl]-methanone | HCID 16727356 | — |
| Product | HCID 16727136 | HCID 16727136 | 51% |
Reaction Steps
The title compound was synthesized in analogy to example 18 from (4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-pyrrolo[2,3-h]pyridin-2-yl]-methanone (example 13), sodium hydride and cyclopropylmethyl bromide, to give the desired product as a light brown oil (51%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622466B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-1df2949e0f574d4aa6e4b6cacb3f7f32 |
| Source note | uspto-grants-2009_11 |