HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Bromopropane → (4,4-Difluoro-piperidin-1-yl)-[1-isopropyl-5-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-1H-pyrrolo[2,3-b]pyridin-2-yl]-methanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Bromopropane | HCID 6358 | — |
| Edukt | Sodium hydride | HCID 24758 | — |
| Edukt | (4,4-Difluoro-piperidin-1-yl)-{1-methanesulfonyl-5-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-1H-pyrrolo[2,3-b]pyridin-2-yl}-methanone | HCID 16727134 | — |
| Produkt | (4,4-Difluoro-piperidin-1-yl)-[1-isopropyl-5-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-1H-pyrrolo[2,3-b]pyridin-2-yl]-methanone | HCID 68423926 | 26% |
Reaktionsschritte
The title compound was synthesized in analogy to example 18 from (4,4-difluoro-piperidin-1-yl)-{1-methanesulfonyl-5-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-1H-pyrrolo[2,3-b]pyridin-2-yl}-methanone (example 20), sodium hydride and 2-bromopropane, to give the desired product as a colorless oil (26%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07622466B2 |
| Quelldatensatz | uspto-grants-2009_11 |
| ORD ID | ord-37316995c9d04d4da48f46c16f7ee4a9 |
| Quellennotiz | uspto-grants-2009_11 |