HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromoacetonitrile → {2-(4,4-Difluoro-piperidine-1-carbonyl)-5-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-pyrrolo[2,3-b]pyridin-1-yl}-acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromoacetonitrile | HCID 11534 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (4,4-Difluoro-piperidin-1-yl)-{1-methanesulfonyl-5-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-1H-pyrrolo[2,3-b]pyridin-2-yl}-methanone | HCID 16727134 | — |
| Product | {2-(4,4-Difluoro-piperidine-1-carbonyl)-5-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-pyrrolo[2,3-b]pyridin-1-yl}-acetonitrile | HCID 68422349 | 3% |
Reaction Steps
The title compound was synthesized in analogy to example 18 from (4,4-difluoro-piperidin-1-yl)-{1-methanesulfonyl-5-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-1H-pyrrolo[2,3-b]pyridin-2-yl}-methanone (example 20), sodium hydride and bromoacetonitrile, to give the desired product as a light yellow oil (3%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622466B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-2655e61b3162497f898851b25fef5a82 |
| Source note | uspto-grants-2009_11 |