HuagongsheHuagongshe Chemistry Print Report · For research reference only
Colchicine → 2-Methyl-cyclopropanecarboxylic acid (3,9,10,11-tetramethoxy-6,7-dihydro-5h-dibenzo[a,c]cyclohepten-5-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Colchicine | HCID 6167 | — |
| Reactant | 2-Chloro-3-methylbenzoic acid | HCID 139879 | — |
| Product | 2-Methyl-cyclopropanecarboxylic acid (3,9,10,11-tetramethoxy-6,7-dihydro-5h-dibenzo[a,c]cyclohepten-5-yl)-amide | HCID 76653798 | — |
Reaction Steps
The same method used in Example 25 was carried out to obtain the title compound 41 (95 mg, Yield: 76%) except that (−)-7-deacetyl-9-methoxy allocolchicine was used instead of (−)-thiodeacetyl colchicine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622612B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-4f8308d572524d96bb6f3cd78b07ed15 |
| Source note | uspto-grants-2009_11 |