Trityl chloride → HCID 57941469, compound

Participants

Reaction Steps

Triphenylmethyl chloride (1.1 g, 3.6 mmol) was added to a solution of ethyl 3-(trifluoromethyl)-pyrazole-4-carboxylate (0.75 g, 3.6 mmol) and triethylamine (1 mL, 7.2 mmol) in N,N-dimethylformamide (12 mL). This mixture was stirred at room temperature overnight, then the solvent was evaporated and the residue was diluted with water (30 mL) and extracted with ethyl acetate. The organic extract was washed with water and brine, dried (magnesium sulfate), filtered, evaporated, and chromatographed (10% ethyl acetate/petroleum ether) to give 3-trifluoromethyl-1-trityl-1H-pyrazole-4-carboxylic acid ethyl ester (1.28 g, 79%).

Provenance & Evidence