4-Fluoro-2-(trifluoromethyl)benzyl bromide → HCID 57941424, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (4S,7R)-1,7,8,8-tetramethyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one (Intermediate 19; 210 mg, 1.02 mmol) and 4-fluoro-2-trifluoromethyl-benzyl bromide (470 μL, 3.04 mmol) in N,N-dimethylformamide (10 mL) was heated at 100° C. overnight. The reaction mixture was evaporated and the residue was purified using a Biotage 40M system, eluting with 0-0.5% methanol/chloroform, followed by drying under high vacuum to give (4S,7R)-2-(4-fluoro-2-trifluoromethyl-benzyl)-1,7,8,8-tetramethyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one (215 mg, 55%) as an off-white solid. APCI-MS (M+H) 383.

Provenance & Evidence