HCID 57941341, compound → HCID 57941479, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (4S,7R)-1,7,8,8-tetramethyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one (Intermediate 19; 100 mg, 0.49 mmol) and 4-bromomethyl-3-trifluoromethyl-1-trityl-1H-pyrazole (0.23 g, 0.49 mmol) in N,N-dimethylformamide (5 mL) was heated at 100° C. over the weekend. The reaction mixture was evaporated and the residue was purified by flash chromatography, eluting with 3% methanol/dichloromethane, followed by drying under high vacuum to give (4S,7R)-1,7,8,8-tetramethyl-2-(3-trifluoromethyl-1-trityl-1H-pyrazol-4-ylmethyl)-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one (213 mg, 73%).

Provenance & Evidence