HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → Phenol, 5-iodo-2-(1-methylethoxy)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 5-Iodo-2-isopropoxyphenyl acetate | HCID 58789145 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Lithium Hydroxide | HCID 3939 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Phenol, 5-iodo-2-(1-methylethoxy)- | HCID 58788960 | 82.7% |
Reaction Steps
To a solution of 5-iodo-2-isopropoxyphenyl acetate (10 mmol) in MeOH (5 mL) and THF (15 mL), LiOH (1.0 M, 15 mL) was added at 0° C. After the mixture was stirred at rt for 3.0 h, 5% citric acid (30 mL) and diethyl ether (150 mL) was added. The organic extract was washed with brine, dried over Na2SO4 and evaporated to give 5-iodo-2-isopropoxyphenol (2.3 g) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622585B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-66f57bcf9143460a907071c6805b1da7 |
| Source note | uspto-grants-2009_11 |