HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | 2-(3-Sulfamoyl-phenyl)-pyrrole-1-carboxylic acid tert-butyl ester | HCID 57942815 | — |
| Catalyst | Platinum | HCID 23939 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | 3-Pyrrolidin-2-yl-benzenesulfonamide | HCID 57942735 | — |
Reaction Steps
3B (290 mg, 0.9 mmol) was hydrogenated in EtOH (9.0 mL) and HOAc (0.15 mL) with Pt/C (5% wt, 100 mg) using a H2 balloon for 2 days. After filtration and evaporation of solvent, the crude product was stirred in EtOAc (1.0 mL) and 4.0 N HCl/dioxane (4.3 mL, 18 eq) at rt for 1.0 h. After removal of solvent, 3C was obtained as HCl salt. 1H NMR (400 MHz, Methanol-d4) δ ppm 2.26 (m, 3H) 2.55 (m, 1H) 3.49 (m, 2H) 4.74 (dd, J=10.11, 6.59 Hz, 1H) 7.66 (t, J=7.69 Hz, 1H) 7.74 (m, 1H) 7.97 (d, J=7.91 Hz, 1H) 8.04 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622585B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-746267a608724c8fadab1f50a424bd47 |
| Source note | uspto-grants-2009_11 |