Acetic Acid → Tert-butyl 2-(3-acetamidophenyl)pyrrolidine-1-carboxylate

Participants

Reaction Steps

4A (870 mg, 3.0 mmol) was hydrogenated in EtOH (12 mL) and HOAc (0.7 mL) with Pt/C (5% wt, 250 mg) using a H2 balloon for 2 days. After filtration and evaporation of solvent, the crude product was stirred in acetic anhydride (8.0 mL) for 20 min. After removal of acetic anhydride under high vacuum, the intermediate tert-butyl 2-(3-acetamidophenyl)pyrrolidine-1-carboxylate (316 mg, 35% yield for 2 steps) was obtained by chromatography (EtOAc/hexanes=1/1). This intermediate (310 mg, 1.0 mmol) was stirred in EtOAc (1.0 mL) and 4.0 N HCl/dioxane (4.4 mL, 18 eq) at rt for 1.0 h. After removal of solvent, 4B was obtained as HCl salt. 1H NMR (400 MHz, Methanol-d4) δ ppm 2.14 (s, 3H) 2.24 (m, 3H) 2.48 (m, 1H) 3.45 (m, 2H) 4.61 (m, 1H) 7.22 (d, J=7.47 Hz, 1H) 7.40 (t, J=7.69 Hz, 1H) 7.49 (m, 1H) 7.84 (s, 1H).

Provenance & Evidence