Water → HCID 131727784, compound

Participants

Reaction Steps

To 13A (0.24 g, 0.63 mmol) in methanol (3 mL) was added Oxone® (1.16 g, 1.90 mmol) in water (3 mL) at 0° C. The reaction was stirred for 3 h at rt. The reaction was quenched with 5% sodium bisulfite and then neutralized with 1 M sodium hydroxide. The solvent was evaporated and the aqueous layer was extracted with dichloromethane (3×). The organic extracts were combined, washed with saturated sodium chloride and dried over sodium sulfate. The solvent was evaporated and the crude residue was purified by flash column chromatography to give 0.17 g of 13B.

Provenance & Evidence