1-tert-Butyl 3-methyl 2-(2-(isopropylsulfonyl)-5-nitrophenyl)pyrrolidine-1,3-dicarboxylate → HCID 57942794, compound

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Reaction Steps

To palladium on carbon (0.5 g) was added 20E in methanol (50 mL) carefully under a stream of nitrogen. The vessel was flushed and degassed with nitrogen gas (3×) and a balloon containing hydrogen gas was introduced. The reaction was stirred at rt overnight. The catalyst was filtered through celite and washed with methanol several times. The filtrate and the combined washings were evaporated and dried to give 2.0 g of crude 20F.

Provenance & Evidence