反应详情

温度

120 °C

A sealable tube was charged with 83E (770 mg, 3.98 mmol), copper (I) oxide (30 mg) and ˜12M NH3 in ethylene glycol (5 mL). The tube was sealed and the reaction was heated to 120° C. for 72 h. After cooling to rt, the reaction was diluted with methanol and was purified via preparative HPLC (MeOH/water/TFA) to provide 83F (832 mg, 72%). LC-MS: 175.23 (M+H)+.

1. customThe tube was sealed
2. temperatureAfter cooling to rt
3. customwas purified via preparative HPLC (MeOH/water/TFA)