Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-Chloro-6-methoxyisoquinoline | HCID 21901074 | — |
| Catalyst | HCID 178419072 | HCID 178419072 | — |
| Solvent | Ethylene Glycol | HCID 174 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-Methoxyisoquinolin-1-amine | HCID 15538409 | 72% |
Reaction Steps
A sealable tube was charged with 83E (770 mg, 3.98 mmol), copper (I) oxide (30 mg) and 12M NH3 in ethylene glycol (5 mL). The tube was sealed and the reaction was heated to 120° C. for 72 h. After cooling to rt, the reaction was diluted with methanol and was purified via preparative HPLC (MeOH/water/TFA) to provide 83F (832 mg, 72%). LC-MS: 175.23 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07622585B2 |
|---|
| Source dataset | uspto-grants-2009_11 |
|---|
| ORD ID | ord-a48a5e2c64bd44ab84c2cb801ef440f5 |
|---|
| Source note | uspto-grants-2009_11 |
|---|
