Potassium Cyanide → 2,4-Difluoro-α-hydroxy-5-methoxybenzeneacetonitrile

Participants

Reaction Steps

To 98A (506 mg, 2.94 mmol) in ethyl acetate (10 mL) was added a solution of KCN (574 mg, 8.82 mmol) and NaHSO3 (917 mg, 8.82 mmol) dissolved in H2O (10 mL). The reaction was stirred at rt for 48 h. It was extracted with ethyl acetate (2×50 mL). The combined organic extracts were dried and concentrated to give 98B as an oil. It was used for next step without purification.

Provenance & Evidence