o-Fluorobenzaldehyde → 2-(Ethylsulfanyl)benzaldehyde
Reaction equation
FC1C=CC=CC=1C=O.[CH:10]([S:13][C:14]1[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=1[CH:16]=[O:17])(C)[CH3:11]>>[CH2:10]([S:13][C:14]1[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=1[CH:16]=[O:17])[CH3:11]Participants
3
Procedure
114A (10.4 g, 78% yield) was prepared from 2-fluorobezaldehyde (10 g, 81 mmol) and thioethane (5.5 g, 89 mmol) using a procedure similar to that used in the preparation of 11A. 1H NMR (400 MHz, Methanol-d4) δ ppm 1.23-1.42 (m, 3H) 2.98 (q, J=7.34 Hz, 2H) 7.17-7.37 (m, 1H) 7.38-7.64 (m, 2H) 7.81 (dd, J=7.70, 1.59 Hz, 1H) 10.30 (s, 1H).
Sources & evidence
- ORD record
- ord-2e00be5c901147ababb9c93327081b03
- Source dataset
- uspto-grants-2009_11
- Patent number
- US07622585B2
Reaction notes
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