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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1438162Generated: November 1, 2026

2-(3-Ethoxy-5-ethyl-2-fluorophenyl)-2-hydroxyacetonitrile → 2-(5-Ethyl-2-fluoro-3-methoxyphenyl)-2-hydroxyacetonitrile

https://huagongshe.com/reaction/1438162

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(3-Ethoxy-5-ethyl-2-fluorophenyl)-2-hydroxyacetonitrileHCID 57942800—
Reactant5-Ethyl-2-fluoro-3-methoxybenzaldehydeHCID 59838048—
Product2-(5-Ethyl-2-fluoro-3-methoxyphenyl)-2-hydroxyacetonitrileHCID 59838005—

Reaction Steps

119B was prepared from 119A using a procedure similar to that used in the preparation of 118E. 1H NMR (400 MHz, CDCl3) δ ppm 1.23 (t, J=7.47 Hz, 3H) 2.64 (q, J=7.62 Hz, 2H) 3.89 (s, 3H) 5.76 (s, 1H) 6.86 (dd, J=7.91, 2.20 Hz, 1H) 6.98 (dd, J=5.93, 1.98 Hz, 1H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07622585B2
Source datasetuspto-grants-2009_11
ORD IDord-99bd70eb62ba42deaace1ff199e1c0b3
Source noteuspto-grants-2009_11