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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1438163Generated: November 4, 2026

Methyl 2-(3-ethoxy-5-ethyl-2-fluorophenyl)-2-hydroxyacetate → Methyl 2-(5-ethyl-2-fluoro-3-methoxyphenyl)-2-hydroxyacetate

https://huagongshe.com/reaction/1438163

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 2-(3-ethoxy-5-ethyl-2-fluorophenyl)-2-hydroxyacetateHCID 57942688—
Reactant2-(5-Ethyl-2-fluoro-3-methoxyphenyl)-2-hydroxyacetonitrileHCID 59838005—
ProductMethyl 2-(5-ethyl-2-fluoro-3-methoxyphenyl)-2-hydroxyacetateHCID 59838057—

Reaction Steps

119C was prepared from 119B using a procedure similar to that used in the preparation of 118F. 1H NMR (400 MHz, CDCl3) δ ppm 1.21 (t, J=7.69 Hz, 3H) 2.59 (q, J=7.47 Hz, 2H) 3.76 (s, 3H) 3.87 (s, 3H) 5.38 (s, 1H) 6.65-6.85 (m, 2H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07622585B2
Source datasetuspto-grants-2009_11
ORD IDord-d116da0978604a0c8d50f494b347d03a
Source noteuspto-grants-2009_11